Latest findings · Appetite ·
CBD and appetite: healthy adults ate 193 kcal more after CBD, without feeling hungrier
Small human RCTs (n=15, n=17) AI-graded ⓘ
AI-graded: the grade and plain-words summary were written by AI from the cited studies; PubMed and DOI links were checked automatically. Not reviewed by a doctor. Always check the source.
In plain words
A 2026 crossover RCT: after about 300 mg of CBD isolate, 15 healthy adults ate 193 kcal more at a buffet lunch than on placebo (979 vs 786 kcal), without feeling hungrier.
But in 17 older adults (65+) with poor appetite, a THC + CBD spray (Sativex) didn't change appetite or appetite hormones (GLP-1, ghrelin).
Studies (PubMed)
- RCTJohnson et al., Appetite 2026 PMID 41825697 · DOICrossover RCT (n=15 healthy). 298 mg CBD isolate: 979 vs 786 kcal at ad lib lunch; no change in subjective appetite.
- RCTBornæs et al., Nutrients 2026 PMID 42514343 · DOISecondary analysis of crossover RCT (n=17, age 65+, poor appetite). Sativex: no significant change in appetite, GLP-1, ghrelin.
Studies suggest; they do not prove. Animal results may not apply to people. Not medical advice; talk to a doctor.
More findings
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- Anxiety + mood: CBD vs THC for anxiety: CBD and balanced flower groups improved far more than THC-only
- Chronic pain: THC:CBD ratio and chronic pain: balanced or high-THC gave small drops; low-THC/high-CBD may not help
- Migraine: THC + CBD flower vs migraine: 67% got relief at 2 hours, vs 47% on placebo
- Inflammation / arthritis: β-caryophyllene and arthritis: it cut swelling in rats, while a THC pill didn't beat placebo for knee pain